SPC-149
Phosphoserine Antibody
Cannot supply to this region.
- SKU:
- SPC-149
- Additional Names:
- O-phospho-L-serine, Phospho-serine, OPS, Phospho-ser, pS, pSer
- Application:
- ELISA, IHC, WB, IF, ICC, IP
- Concentration:
- 0.25 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS, 50% glycerol, 0.01% sodium azide
- Immunogen:
- Phosphoserine conjugated to KLH, and phosvitin mixture
- Extra Details:
- Phosphoserine is a post-translationally modified form of the amino acid serine, resulting from phosphorylation by serine/threonine kinases. This modification plays a critical role in regulating protein function, localization, and interactions, particularly in the central nervous system. In neurons, phosphoserine is involved in signal transduction, synaptic plasticity, and cytoskeletal dynamics. Aberrant serine phosphorylation has been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. For example, hyperphosphorylation of tau protein at serine residues contributes to neurofibrillary tangle formation and neuronal dysfunction in Alzheimer's disease. Phosphoserine also modulates the activity of transcription factors, ion channels, and enzymes involved in oxidative stress responses and apoptosis. As a dynamic and reversible modification, it offers a promising target for therapeutic intervention and biomarker development in neurodegeneration.
- Shipping Conditions:
- Blue Ice