Erk1/2 Antibody

Cannot supply to this region.

SKU:: SPC-120
Additional Names:: ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3
Application:: Flow Cytometry, IHC, WB, IF, ICC
Concentration:: 1 mg/ml
Species Reactivity:: Rat
Purification:: Affinity Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Host:: Rabbit
Reactivities:: Bovine, Human, Mouse, Rat, Ovine, Insect/Arthropod
ABP:: IMP-GEN-2015-06 < 10% Serum <100ml
Buffer:: PBS pH7.4, 50% glycerol, 0.09% sodium azide
Immunogen:: A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.
Uniprot:: P21708
Synonyms:: Erk-1;ERK1;ERT2;Esrk1;extracellular signal-regulated kinase 1;insulin-stimulated MAP2 kinase;MAP kinase 1;MAP kinase 3;MAP kinase isoform p44;MAPK 1;MAPK 3;MAPK1;microtubule-associated protein 2 kinase;mitogen-activated 3;mitogen-activated protein kinase 1;mitogen-activated protein kinase 3;MNK1;p44;p44-ERK1;p44erk1;p44mapk;Prkm3
Extra Details:: Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation-hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.

Shipping Conditions:: Blue Ice