SPC-114
PDI Antibody
Cannot supply to this region.
- SKU:
- SPC-114
- Additional Names:
- Thioredoxin domain containing 5, ERP46, UNQ364, MGC3178, FLJ21353, FLJ90810, thioredoxin related protein, endothelial protein disulphide isomeras
- Application:
- IHC, WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- Reactivities:
- Bovine, Canine, Hamster, Human, Mouse, Porcine, Rat, Guinea Pig, Ovine
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- AA499-509 of Rat PDI
- Uniprot:
- P04785
- Synonyms:
- cellular thyroid hormone-binding protein;PDI;PDIR;Prolyl 4-hydroxylase subunit beta;prolyl 4-hydroxylase, beta polypeptide;Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide);protein disulfide-isomerase
- Extra Details:
- Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER). In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress-common in neurodegenerative diseases-PDI expression is upregulated as part of the unfolded protein response (UPR). However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer's, ALS, and Parkinson's disease. PDI's dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration.
- Shipping Conditions:
- Blue Ice