SMC-631
SAP97 Antibody, Clone G28
Cannot supply to this region.
- SKU:
- SMC-631
- Additional Names:
- SAP97 Antibody, DLGH1 Antibody, DLGH 1 Antibody, DLG1 Antibody, DLG 1 Antibody, Synapse-associated protein 97 Antibody, Disks large homolog 1 Antibody, SAP-97 Antibody, SAP 97 Antibody
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- MabSelect™ PrismA
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS pH 7.4, 0.02% Proclin 300, 50% glycerol
- Immunogen:
- Fusion protein, AA #1-104 (N-terminus) of rat SAP97.
- Clone:
- G28
- Uniprot:
- Q62696
- Synonyms:
- discs large homolog 1, scribble cell polarity complex component;discs, large homolog 1;disks large homolog 1;Dlgh1;Drosophila discs-large tumor suppressor homologue (synapse associated protein);SAP97;synapse-associated protein 97
- Extra Details:
- SAP97 (Synapse-Associated Protein 97), a member of the MAGUK family, is a critical scaffolding protein involved in the trafficking and localization of glutamate receptors, which are essential for synaptic plasticity and cognitive function. Mutations in the DLG1 gene encoding SAP97 have been linked to schizophrenia, with studies showing that these mutations enhance glutamatergic synapse strength in the dentate gyrus and impair episodic memory processing. SAP97 also mediates a non-conventional secretory pathway for NMDA receptors via dendritic Golgi outposts, highlighting its unique role in receptor sorting and synaptic regulation. Furthermore, SAP97 regulates the trafficking of ADAM10, a key A Alpha-secretase involved in amyloid precursor protein processing, implicating it in Alzheimer's disease mechanisms. Our Anti-Rat SAP97 recombinant monoclonal antibody has been demonstrated to detect the target in rodent brain lysates and in cell culture lines.
- Shipping Conditions:
- Blue Ice