SMC-610
DENND4C Antibody
Cannot supply to this region.
- SKU:
- SMC-610
- Additional Names:
- DENN domain-containing protein 4C
- Application:
- WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Full Length Human Recombinant Dennd4c protein
- Clone:
- 3E8
- Uniprot:
- Q5VZ89
- Synonyms:
- bA513M16.3;C9orf55;C9orf55B;DENN domain-containing protein 4C;DENN/MADD domain containing 4A pseudogene;DENN/MADD domain containing 4C;RAB10GEF
- Extra Details:
- DENND4C is a guanine nucleotide exchange factor (GEF) for Rab10, a small GTPase involved in vesicle trafficking and membrane recycling. DENND4C regulates GLUT4 translocation and interacts with the retromer complex, linking it to endosomal sorting and cellular metabolism. Mutations in DENND4C have been associated with neurodevelopmental syndromes such as Alkuraya-Kucinskas and Koolen-De Vries, suggesting a broader role in brain development and function. Its involvement in membrane trafficking pathways positions DENND4C as a candidate for investigation in neurodegenerative diseases characterized by endolysosomal dysfunction.
- Shipping Conditions:
- Blue Ice