VPS35 Antibody, Clone 8A3

Cannot supply to this region.

SKU:: SMC-604
Additional Names:: VPS35, VPS35 Retromer Complex Component, Vacuolar Protein Sorting-Associated Protein 35, Vacuolar Protein Sorting 35 Homolog, Vesicle Protein Sorting 35, MEM3, PARK17, FLJ10752, HVPS35, Maternal-Embryonic 3, TCCCTA00141
Application:: IHC, WB, IF, ICC, IP
Concentration:: 1 mg/ml
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Host:: Mouse
Reactivities:: Human, Mouse, Rat
ABP:: IMP-GEN-2015-06 < 10% Serum <100ml
Buffer:: PBS pH7.4, 50% glycerol, 0.09% sodium azide
Immunogen:: Full length recombinant human VSP35
Clone:: 8A3
Uniprot:: Q96QK1
Synonyms:: hVPS35;maternal-embryonic 3;MEM3;PARK17;vacuolar protein sorting 35 homolog;vacuolar protein sorting-associated protein 35;Vesicle protein sorting 35
Extra Details:: Vacuolar Protein Sorter 35 (VPS35) is a core component of the retromer complex, a critical intracellular trafficking system responsible for the endosome-to-Golgi retrieval of membrane proteins. This pathway is essential for maintaining protein homeostasis, synaptic function, and neuronal survival. Mutations in VPS35-most notably the D620N variant-have been directly linked to familial and sporadic forms of Parkinson's disease (PD). These mutations impair retromer function, leading to disrupted recycling of key neuronal receptors and transporters. Dysfunctional VPS35 also contributes to mitochondrial fragmentation, oxidative stress, and impaired autophagy-cellular processes that are central to the pathogenesis of neurodegenerative diseases. Beyond Parkinson's, VPS35 dysfunction has been implicated in Alzheimer's disease and other proteinopathies, where it affects the trafficking of amyloid precursor protein (APP) and tau. Its role in regulating endosomal sorting and mitochondrial dynamics positions VPS35 as a critical node in the cellular pathways that maintain neuronal integrity. As a result, VPS35 is emerging as a promising therapeutic target in neurodegenerative disease research. Restoring or enhancing retromer function may offer novel strategies to counteract protein misfolding, synaptic loss, and neuroinflammation.

Shipping Conditions:: Blue Ice