Alpha Synuclein Antibody, Clone 3F8

Cannot supply to this region.

SKU:: SMC-532
Additional Names:: Alpha Synuclein, A Alpha-Synuclein, SNCA, Snca, SYN, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease familial 1, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4
Application:: ELISA, IHC, WB, IF, ICC, Dot blot
Concentration:: 1 mg/ml
Species Reactivity:: Mouse
Purification:: Protein G Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Host:: Mouse
Reactivities:: Human, Mouse, Rat
ABP:: IMP-GEN-2015-06 < 10% Serum <100ml
Buffer:: PBS pH7.4, 50% glycerol, 0.09% sodium azide
Immunogen:: Mouse alpha synuclein aggregate
Clone:: 3F8
Uniprot:: O55042
Synonyms:: al;alp;alpha-Syn;alpha-synuclein;alphaSYN;NACP;non-A beta component of AD amyloid;non-A4 component of amyloid;Non-A4 component of amyloid precursor
Extra Details:: Alpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is highly concentrated at presynaptic nerve terminals, suggesting a key role in synaptic transmission and plasticity (1). In addition to its synaptic localization, alpha-synuclein is abundantly expressed in mitochondria-rich brain regions, including the olfactory bulb, hippocampus, striatum, and thalamus, implicating it in mitochondrial function and energy metabolism (2). Functionally, alpha-synuclein has been shown to interact significantly with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. This interaction may be critical for maintaining neuronal structure and function, particularly in long-range axonal projections. Importantly, alpha-synuclein is essential for normal cognitive development. Genetic or functional inactivation of SNCA has been associated with impairments in spatial learning and working memory, underscoring its role in higher-order brain functions (4). Given its physiological importance and pathological aggregation in disorders such as Parkinson's disease and dementia with Lewy bodies, alpha-synuclein remains a focal point in neurodegenerative disease research. Understanding its normal function and mechanisms of misfolding is vital for developing targeted diagnostics and therapeutics.

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