SMC-494
GABAA Receptor Alpha 5 Antibody, Clone N415/24
Cannot supply to this region.
- SKU:
- SMC-494
- Additional Names:
- Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, GABRA5, Gamma aminobutyric acid A receptor alpha 5, GBRA5_HUMAN
- Application:
- IHC, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS pH7.4, 50% glycerol, 0.1% sodium azide
- Immunogen:
- Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA A Receptor Alpha5.
- Clone:
- N415/24 (Formerly sold as S415-24)
- Uniprot:
- P31644
- Synonyms:
- DEE79;EIEE79;GABA(A) receptor subunit alpha-5;gamma-aminobutyric acid (GABA) A receptor, alpha 5;gamma-aminobutyric acid receptor subunit alpha-5;gamma-aminobutyric acid type A receptor alpha5 subunit
- Extra Details:
- The GABA-A receptor alpha 5 subunit (GABRA5) is a critical component of the GABA-A receptor complex, the brain's primary fast-acting inhibitory neurotransmitter system. As part of the ligand-gated ion channel superfamily, GABRA5 is predominantly expressed in the hippocampus, where it plays a central role in modulating tonic inhibition, synaptic plasticity, and cognitive function. Recent research has highlighted GABRA5 as a promising target in neurodegenerative disease, particularly Alzheimer's disease. Inverse agonists selective for GABRA5-containing receptors have shown potential in enhancing learning and memory by reducing excessive inhibitory tone, which is often elevated in neurodegenerative states. This modulation of GABRA5 activity may help restore excitatory-inhibitory balance, improve cognitive performance, and slow disease progression. Beyond Alzheimer's, GABRA5 is also being investigated for its role in age-related cognitive decline and other neurological disorders characterized by impaired GABAergic signaling. Its unique pharmacological profile and region-specific expression make it an attractive candidate for precision therapies aimed at cognitive enhancement and neuroprotection. As neuroscience advances toward targeted interventions, GABRA5 stands out as a key molecular player in the development of next-generation treatments for neurodegenerative diseases.
- Shipping Conditions:
- Blue Ice