SMC-490
Nav beta 3 Antibody, Clone N396/29
Cannot supply to this region.
- SKU:
- SMC-490
- Additional Names:
- NaVbeta3, SCN3B, Scn3b, Sodium channel subunit beta-3, KIAA1158
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS pH7.4, 50% glycerol, 0.1% sodium azide
- Immunogen:
- Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
- Clone:
- N396/29 (Formerly sold as S396-29)
- Uniprot:
- Q9JK00
- Synonyms:
- Scnb3;sodium channel beta 3 subunit;sodium channel subunit beta-3;sodium channel, voltage-gated, type III, beta subunit
- Extra Details:
- NaVB Beta3 (encoded by SCN3B) is a regulatory subunit of voltage-gated sodium channels that modulates channel gating kinetics and neuronal excitability. Unlike other B Beta subunits, NaVB Beta3 slows inactivation and promotes persistent sodium currents, which enhance synaptic input summation and increase neuronal responsiveness. This property may contribute to hyperexcitability in specific neuronal populations, a feature observed in epilepsy and neurodegenerative disorders. NaVB Beta3 also interacts with neurofascin, facilitating the localization and retention of sodium channels at the nodes of Ranvier in developing and mature myelinated axons. This interaction is essential for saltatory conduction and efficient neural signaling. Disruption of SCN3B has been linked to Brugada syndrome, highlighting its role in excitable tissue function. In the context of neurodegeneration, altered NaVB Beta3 expression or function may contribute to impaired action potential propagation, synaptic dysfunction, and neuronal vulnerability. Its role in modulating persistent sodium currents suggests a potential link to excitotoxicity and calcium overload, both of which are implicated in diseases such as ALS and Alzheimer's disease. NaVB Beta3 thus represents a promising target for understanding and modulating neuronal excitability in neurodegenerative conditions.
- Shipping Conditions:
- Blue Ice