Neuroligin-1 Antibody, Clone N97A/31

Cannot supply to this region.

SKU:: SMC-463
Additional Names:: NLG 1, KIAA1070, MGC45115, Neuroligin-1, NL1, NLG1, Nlgn1
Application:: IHC, WB, IF, ICC
Concentration:: 1 mg/ml
Species Reactivity:: Rat
Purification:: Protein G Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Host:: Mouse
Reactivities:: Human, Mouse, Rat
Buffer:: PBS pH7.4, 50% glycerol, 0.1% sodium azide
Immunogen:: Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical). Human: 99% identity (125/126 amino acids identical) >40% identity with Neuroligin-2 and -3.
Clone:: N97A/31 (Formerly sold as S97A-31)
Uniprot:: Q62765
Synonyms:: neuroligin I;neuroligin-1
Extra Details:: Neuroligin 1 (NLGN1) is a postsynaptic cell adhesion molecule critical for the formation and maturation of excitatory synapses. As a member of the neuroligin family, NLGN1 interacts with presynaptic neurexins to establish trans-synaptic connections that regulate synaptic specificity and plasticity. In the adult brain, NLGN1 is essential for long-term potentiation (LTP), synaptic remodeling, and memory formation, particularly within the hippocampus and amygdala. Dysregulation of NLGN1 expression or function has been linked to impaired synaptic transmission, cognitive deficits, and neurodevelopmental disorders. In neurodegenerative diseases, such as Alzheimer's disease, synaptic loss precedes neuronal death. Altered NLGN1 signaling may contribute to early synaptic dysfunction, making it a potential biomarker and therapeutic target. NLGN1 also participates in activity-dependent synaptic scaling, suggesting a role in maintaining excitatory-inhibitory balance under pathological conditions. Understanding NLGN1's role in synaptic maintenance and plasticity provides insight into the molecular mechanisms underlying cognitive decline and offers avenues for synapse-targeted therapies in neurodegeneration.

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