Protocadherin Gamma Antibody, Clone N159/5

Cannot supply to this region.

SKU:: SMC-454
Additional Names:: PCDH gamma A, PCDH-gamma-A, PCDHGA, Protocadherin gamma A, Protocadherin gamma subfamily A, Gamma Protocadherin A (pan), Pan-Gamma-Protocadherin-A, Pan Gamma Protocadherin A, PCDHGA1, PCDHGA4, PCDHGC4, Protocadherin gamma-A1, Protocadherin gamma-A4, Protocadherin gamma-C4
Application:: IHC, WB, IF, ICC
Concentration:: 1 mg/ml
Species Reactivity:: Mouse
Purification:: Protein G Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Host:: Mouse
Reactivities:: Human, Mouse, Rat
Buffer:: PBS pH7.4, 50% glycerol, 0.1% sodium azide
Immunogen:: Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941). 99% identity with human (123/124 amino acids).
Clone:: N159/5 (Formerly sold as S159-5)
Uniprot:: Q91XZ0
Synonyms:: protocadherin gamma-A1
Extra Details:: Protocadherin Gamma is part of a large gene cluster on chromosome 5, organized in an immunoglobulin-like tandem array. This cluster includes 22 genes divided into three subfamilies (A, B, and C), each encoding neural cadherin-like cell adhesion proteins. Each gene contains a variable region exon encoding six extracellular cadherin domains and a transmembrane region, followed by three constant region exons encoding a shared cytoplasmic domain. This structure enables diverse cell-cell recognition and adhesion mechanisms in the brain. Protocadherin Gamma proteins are critical for establishing and maintaining specific neuronal connections. Their alternative splicing and combinatorial expression contribute to synaptic specificity and neural circuit formation. Dysregulation of these proteins may impair synaptic connectivity and has been implicated in neurodevelopmental and neurodegenerative disorders.

Shipping Conditions:: Blue Ice