SMC-435
Alpha-2C Adrenergic Antibody, Clone N330A/80
Cannot supply to this region.
- SKU:
- SMC-435
- Additional Names:
- Alpha-2C Adrenergic Receptor, Alpha-2C Adrenoceptor, Alpha-2C Adrenoreceptor, ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, Alpha2-AR-C4, Alpha2-C4, Adrenoceptor Alpha 2C, Adrenergic receptor alpha 2C
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor
- Clone:
- N330A/80 (Formerly sold as S330A-80)
- Uniprot:
- P18825
- Synonyms:
- ADRA2L2;ADRA2RL2;ADRARL2;adrenergic, alpha-2C-, receptor;alpha-2 adrenergic receptor subtype C4;alpha-2C adrenergic receptor;alpha-2C adrenoceptor;alpha-2C adrenoreceptor;alpha-2CAR;alpha2-AR-C4;ALPHA2CAR
- Extra Details:
- The Alpha-2C Adrenergic Receptor (ADRA2C) is a G protein-coupled receptor that plays a critical role in modulating neurotransmitter release from central adrenergic neurons and sympathetic nerves, particularly in the brain and heart. Widely expressed in the central nervous system, ADRA2C is involved in regulating synaptic transmission, stress responses, and higher-order cognitive and behavioral functions. Two isoforms of ADRA2C are produced via alternative splicing, with predominant expression in brain regions implicated in memory, emotion, and executive function. Beyond the CNS, ADRA2C is also found in peripheral tissues including the heart, kidney, blood, and corpus cavernosum, suggesting a broader physiological role. In the context of neurodegenerative disease, dysregulation of ADRA2C signaling has been linked to impaired noradrenergic tone, altered synaptic plasticity, and neuroinflammation-key features observed in disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Its involvement in modulating cognitive resilience and behavioral regulation positions ADRA2C as a promising biomarker and therapeutic target in neuropsychiatric and neurodegenerative research. Ongoing studies are exploring ADRA2C agonists and antagonists for their potential to restore neurotransmitter balance, enhance cognitive function, and mitigate neurodegenerative progression
- Shipping Conditions:
- Blue Ice