SMC-430D-APC
Notch1 Antibody, Clone N253/32: APC
Cannot supply to this region.
- SKU:
- SMC-430D-APC
- Additional Names:
- Neurogenic locus notch homolog protein 1, hN1, Translocation associated notch protein, TAN1, TAN-1, Motch A, mT14, p300, Motch, Mis6, Neurogenic locus notch protein homolog, NICD, Notch 1 intracellular domain, Notch gene homolog 1 (Drosophila), Notch homolog 1, translocation-associated (Drosophila), NOTCH Drosophila, homolog of 1, Translocation associated notch homolog, Translocation associated notch protein TAN 1, xotch
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Mouse
- Purification:
- Protein G Purified
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- Immunogen:
- Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1
- Clone:
- N253/32 (Formerly sold as S253-32)
- Uniprot:
- Q01705
- Synonyms:
- 9930111A19Rik;lin;lin-12;major type A protein;Mi;Mis6;Motch A;mT14;N;N1;neurogenic locus notch homolog protein 1;Notch gene homolog 1;p300;Ta;Tan1
- Extra Details:
- Notch1 is a transmembrane receptor involved in cell fate determination, synaptic plasticity, and neurogenesis. Following ligand binding, Notch1 undergoes sequential proteolytic cleavages, culminating in the release of the Notch intracellular domain (NICD), which translocates to the nucleus to regulate gene expression. In the nervous system, Notch1 signaling influences neural stem cell maintenance, differentiation, and response to injury. Aberrant Notch1 activation has been implicated in neurodegenerative diseases, where it may contribute to gliosis, inflammation, and impaired neurogenesis. Modulating Notch1 signaling could offer therapeutic strategies for promoting neural repair and mitigating neurodegenerative progression.
- Shipping Conditions:
- Blue Ice