SMC-427
ASIC1 Antibody, Clone N271/44
Cannot supply to this region.
- SKU:
- SMC-427
- Additional Names:
- ASIC1, ACCN2, BNAC2, Acid-sensing ion channel 1, Acid-sensing (proton-gated) ion channel, Amiloride-sensitive cation channel 2 neuronal, Brain sodium channel 2
- Application:
- IHC, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Mouse
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 460-526 (Cytoplasmic C-terminus) of mouse ASIC1
- Clone:
- N271/44 (Formerly sold as S271-44)
- Uniprot:
- Q6NXK8
- Synonyms:
- A;Acc;Accn2;Acid-sensing ion channel;acid-sensing ion channel 1;AI843610;amiloride-sensitive cation channel 2, neuronal;AS;ASIC;ASIC1a;B530003N02Rik;BNa;BNaC2;brain sodium channel 2;degenerin 2
- Extra Details:
- Acid-sensing ion channel 1 (ASIC1), also known as ASIC1a, ACCN2, and BNAC2, is a proton-gated cation channel highly expressed in the central nervous system. It plays a critical role in detecting extracellular pH changes and mediating neuronal excitability in response to acidosis. ASIC1 is encoded as a 4.3-kb transcript and is prominently localized in the rat brain, particularly in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdala, and cerebellum. Functionally, ASIC1 contributes to synaptic plasticity, learning, and memory, and is involved in the modulation of fear and anxiety-related behaviors. Its activation by protons leads to sodium influx, influencing neuronal firing and excitotoxicity under pathological conditions. In the context of neurodegenerative disease, ASIC1 has gained attention for its role in ischemic brain injury, traumatic brain injury, and chronic neuroinflammation. ASIC1a, the predominant isoform in neurons, is permeable to calcium and has been implicated in acidosis-induced neuronal death-a common feature in stroke and neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Given its dual role in physiological signaling and pathological damage, ASIC1 is emerging as a promising therapeutic target. Inhibiting ASIC1 activity may offer neuroprotection by reducing calcium overload and excitotoxicity in vulnerable brain regions. Understanding the spatial expression and functional dynamics of ASIC1 is essential for advancing therapeutic strategies in neurodegenerative disease research.
- Shipping Conditions:
- Blue Ice