SMC-419
mGluR1/5 Antibody, Clone N75/3
Cannot supply to this region.
- SKU:
- SMC-419
- Additional Names:
- mGluR5, mGlu5, GRM5, GPRC1E, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Glutamate receptor metabotropic 5, mGluR5a, mGluR5b, mGluR, Glutamate receptor metabotropic 1, mGlu1, mGluR1, GRM1, GRM 1, GRM1A, GRM1 alpha, GRM1_HUMAN, GPRC1A, Metabotropic glutamate receptor 1, mGluR1 alpha
- Application:
- IHC, WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
- Clone:
- N75/3 (Formerly sold as S75-3)
- Uniprot:
- P31424
- Synonyms:
- glutamate receptor, metabotropic 5;metabotropic glutamate receptor (mGluR5);metabotropic glutamate receptor 5;metabotropic glutamate receptor 5b;mGluR5
- Extra Details:
- mGluR5 (metabotropic glutamate receptor 5) is a subtype of glutamate receptor that regulates synaptic transmission and plasticity via G-protein-coupled signaling. It is predominantly expressed in the hippocampus, cortex, and striatum-regions vulnerable to neurodegeneration. Aberrant mGluR5 activity has been linked to excitotoxicity, calcium dysregulation, and neuroinflammation, contributing to the pathophysiology of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). mGluR5 also interacts with amyloid precursor protein and tau, influencing their aggregation and toxicity. Pharmacological modulation of mGluR5 has shown promise in preclinical models, where antagonists reduce neuronal loss and improve cognitive outcomes. As a key regulator of glutamatergic tone, mGluR5 is a compelling target for therapeutic intervention in neurodegenerative disorders characterized by synaptic dysfunction and excitatory imbalance.
- Shipping Conditions:
- Blue Ice