SMC-416D-APC
Dicer Antibody, Clone N167/7: APC
Cannot supply to this region.
- SKU:
- SMC-416D-APC
- Additional Names:
- Dicer1, DCR, DCR1, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase motif, HERNA, Helicase MOI, KIAA0928, Endoribonuclease Dicer
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Mouse
- Purification:
- Protein G Purified
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- Immunogen:
- Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer
- Clone:
- N167/7 (Formerly sold as S167-7)
- Uniprot:
- Q8R418
- Synonyms:
- 1110006F08Rik;aviD;D12Ertd7;D12Ertd7e;Dice;Dicer1, Dcr-1 homolog;double-strand-specific ribonuclease mDCR-1;endoribonuclease Dicer;mKIAA0928
- Extra Details:
- Dicer is a ribonuclease III enzyme essential for the biogenesis of microRNAs (miRNAs), which regulate gene expression post-transcriptionally. It processes precursor miRNAs into mature ~22-nucleotide miRNAs that guide the RNA-induced silencing complex (RISC) to target mRNAs. In the nervous system, Dicer is critical for neuronal differentiation, synaptic plasticity, and stress responses. Dysregulation of Dicer or miRNA pathways has been implicated in neurodegenerative diseases, including Alzheimer's, ALS, and Huntington's disease. Loss of Dicer function leads to widespread transcriptomic imbalance and neuronal vulnerability, making it a key player in epigenetic regulation and a potential therapeutic target in neurodegeneration.
- Shipping Conditions:
- Blue Ice