SMC-410
GluN1 (NR1, NMDA Receptor 1) Antibody, Clone N308/48
Cannot supply to this region.
- SKU:
- SMC-410
- Additional Names:
- GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic N methyl D aspartate 1, MRD8, Methyl-D-aspartate receptor subunit zeta-1, N methyl D aspartate receptor, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA R1, NMDA Receptor 1, NMDA1, NMDAR, NMDAR1, NMDZ1_HUMAN, NR1
- Application:
- IHC, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
- Clone:
- N308/48
- Uniprot:
- P35439
- Synonyms:
- GluN1;glutamate [NMDA] receptor subunit zeta-1;glutamate receptor ionotropic, NMDA 1;glutamate receptor, ionotropic, N-methyl D-aspartate 1;N-methyl-D-aspartate glutamate receptor;N-methyl-D-aspartate receptor subunit NR1;neurotransmitter receptor;NMD-R1;NMDA R1 receptor C1 cassette;NMDAR1;NR1
- Extra Details:
- The N-methyl-D-aspartate receptor (NMDA receptor or NMDAR) is a glutamate-gated ion channel essential for synaptic plasticity, learning, and memory. Central to its function is the GluN1 subunit, encoded by the GRIN1 gene, which is an obligatory component of all functional NMDAR complexes. Each receptor is a heterotetramer typically composed of two GluN1 subunits and two regionally expressed GluN2 (A-D) subunits. The GluN1 subunit not only anchors the receptor's core structure but also modulates its biophysical and pharmacological properties through alternative splicing, generating multiple isoforms with distinct functional profiles. GluN1's ubiquitous expression and essential role in receptor assembly make it a focal point in neuroscience and neurodegenerative disease research. Dysregulation of GluN1 expression or splicing has been implicated in a range of neurological disorders, including Alzheimer's disease, Huntington's disease, and schizophrenia. Additionally, GluN3 subunits (A and B), which can co-assemble with GluN1, exert inhibitory effects on receptor activity, further influencing disease-relevant signaling pathways. Understanding GluN1's molecular diversity and regulatory mechanisms is critical for developing targeted therapies aimed at restoring NMDAR function in neurodegenerative and neuropsychiatric conditions.
- Shipping Conditions:
- Blue Ice