SMC-407
mGluR1/5 Antibody, Clone N75/33
Cannot supply to this region.
- SKU:
- SMC-407
- Additional Names:
- mGluR5, mGlu5, GRM5, GPRC1E, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Glutamate receptor metabotropic 5, mGluR5a, mGluR5b, mGluR, Glutamate receptor metabotropic 1, mGlu1, mGluR1, GRM1, GRM 1, GRM1A, GRM1 alpha, GRM1_HUMAN, GPRC1A, Metabotropic glutamate receptor 1, mGluR1 alpha
- Application:
- IHC, WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Rat
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
- Clone:
- N75/33 (Formerly sold as S75-33)
- Uniprot:
- P31424
- Synonyms:
- glutamate receptor, metabotropic 5;metabotropic glutamate receptor (mGluR5);metabotropic glutamate receptor 5;metabotropic glutamate receptor 5b;mGluR5
- Extra Details:
- Metabotropic glutamate receptor 5 (mGluR5) is a G-protein-coupled receptor that modulates excitatory neurotransmission and synaptic plasticity in the central nervous system. It plays a critical role in learning, memory, and neurodevelopment. Dysregulation of mGluR5 signaling has been implicated in a range of neurodegenerative and neuropsychiatric disorders, including Alzheimer's disease, Huntington's disease, and fragile X syndrome. Overactivation of mGluR5 can lead to excitotoxicity, neuroinflammation, and synaptic dysfunction. Conversely, pharmacological inhibition of mGluR5 has shown neuroprotective effects in preclinical models by reducing amyloid-beta accumulation, restoring synaptic function, and attenuating cognitive deficits. As a modulator of glutamatergic signaling, mGluR5 represents a promising therapeutic target for restoring neural circuit balance and preventing neurodegenerative progression. Ongoing clinical trials are evaluating mGluR5 antagonists for their efficacy in treating cognitive and behavioral symptoms associated with neurodegeneration.
- Shipping Conditions:
- Blue Ice