SMC-204
EndoPDI Antibody, Clone 2E7/7
Cannot supply to this region.
- SKU:
- SMC-204
- Additional Names:
- Thioredoxin domain containing 5, ERP46, UNQ364, MGC3178, FLJ21353, FLJ90810, thioredoxin related protein, endothelial protein disulphide isomeras
- Application:
- ELISA, IHC, WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthesized peptide - 12 amino acids long (ADGEDGQDPHSK) corresponding to residues 52 - 63 of the Human EndoPDI protein
- Clone:
- 2E7/7
- Uniprot:
- Q8NBS9
- Synonyms:
- ENDOPDI;endoplasmic reticulum protein ERp46;endoplasmic reticulum resident protein 46;endothelial protein disulphide isomerase;epididymis secretory sperm binding protein;ER protein 46;ERP46;HCC-2;HCC2;PDIA15;protein disulfide isomerase family A, member 15;STRF8;thioredoxin domain containing 5 (endoplasmic reticulum);thioredoxin domain-containing protein 5;thioredoxin related protein;thioredoxin-like protein p46;UNQ364
- Extra Details:
- Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER). In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress-common in neurodegenerative diseases-PDI expression is upregulated as part of the unfolded protein response (UPR). However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer's, ALS, and Parkinson's disease. PDI's dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration.
- Shipping Conditions:
- Blue Ice