SMC-197
MDC1 Antibody, Clone P2B11
Cannot supply to this region.
- SKU:
- SMC-197
- Additional Names:
- MDC1, Nuclear factor with BRCT domains1, Mediator of DNA damage checkpoint 1
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Mouse
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Bovine, Human, Mouse
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
- Clone:
- P2B11
- Uniprot:
- Q5PSV9
- Synonyms:
- 6820401C03;AA413496;mediation of DNA damage checkpoint 1;mediator of DNA damage checkpoint protein 1;mKIAA0170;NFBD;Nfbd1
- Extra Details:
- Mediator of DNA Damage Checkpoint 1 (MDC1) is a key regulator of the DNA damage response (DDR), orchestrating the recruitment of repair proteins to sites of double-strand breaks. In post-mitotic neurons, where genomic integrity is critical for long-term function, MDC1 plays a vital role in maintaining neuronal viability. Dysregulation of MDC1 impairs DNA repair efficiency, contributing to the accumulation of DNA lesions observed in neurodegenerative diseases such as Alzheimer's and Huntington's disease. MDC1 also interacts with chromatin remodeling complexes and checkpoint kinases, linking it to broader epigenetic and cell cycle control mechanisms. As DNA damage and genomic instability are emerging hallmarks of neurodegeneration, MDC1 represents a promising target for therapeutic strategies aimed at enhancing neuronal resilience and genomic maintenance.
- Shipping Conditions:
- Blue Ice