SMC-141
LAMP2 Antibody, Clone GL2A7
Cannot supply to this region.
- SKU:
- SMC-141
- Additional Names:
- LAMP2, LAMP-2, Lamp2C, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, CD107b, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, Igp110, Igp2, LampB, MAC3
- Application:
- WB, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Mouse
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rat
- Reactivities:
- Human, Mouse, Rabbit
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Purified preparation of mouse liver lysosomal membranes
- Clone:
- GL2A7
- Uniprot:
- P17047
- Synonyms:
- CD107 antigen-like family member B;CD107b;Lam;Lamp;Lamp II;Lamp-2;Lamp-2a;Lamp-2b;Lamp-2c;LGP-B;lysosomal membrane glycoprotein 2;lysosomal membrane glycoprotein type B;lysosome-associated membrane glycoprotein 2;Mac;Mac3
- Extra Details:
- LAMP2 (Lysosome-Associated Membrane Protein 2) is a transmembrane glycoprotein essential for lysosomal function and autophagy. It facilitates the maturation of autophagic vacuoles and the degradation of cellular debris. LAMP2 is expressed in lysosomes, late endosomes, and at the plasma membrane, where it may mediate cell-cell and cell-matrix interactions. In neurodegenerative diseases, LAMP2 deficiency or dysfunction impairs autophagic clearance, leading to the accumulation of toxic proteins and organelles. This contributes to neuronal death in disorders such as Danon disease, Parkinson's disease, and Alzheimer's disease. LAMP2 also participates in immune responses, promoting leukocyte adhesion and mast cell activation. Its role in lysosomal trafficking and neuroinflammation underscores its importance as a biomarker and therapeutic target in neurodegeneration.
- Shipping Conditions:
- Blue Ice