SMC-135
HSP90 alpha/beta Antibody, Clone Hyb-K41220A
Cannot supply to this region.
- SKU:
- SMC-135
- Additional Names:
- HSP90AA1, HSP90AB1, HSP90-alpha, HSP90-beta, HSP90A, HSP90B, HSP89A, HSP86, HSP84, HSP90Alpha, HSPCA, HSPC1, HSPC2, HSPCB, HSPCAL3, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock 90 kDa protein 1 alpha isoform, Heat shock 84 kDa protein, D6S182, FLJ26984
- Application:
- ELISA, IHC, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat, Yeast
- Buffer:
- PBS pH7.2, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Recombinant human HSP90alpha; Specificity mapped to amino acids 291-304
- Clone:
- Hyb-K41220A
- Uniprot:
- P07900, P08238
- Synonyms:
- D6S182;EL52;epididymis luminal secretory protein 52;epididymis secretory sperm binding protein Li 65p;heat shock 84 kDa;heat shock 86 kDa;heat shock 90kD protein 1, alpha;heat shock 90kD protein 1, alpha-like 4;heat shock 90kD protein 1, beta;heat shock 90kD protein, alpha-like 4;heat shock 90kDa protein 1, alpha;heat shock protein 90 kDa;heat shock protein 90kDa alpha (cytosolic), class A member 1;heat shock protein 90kDa alpha (cytosolic), class B member 1;heat shock protein 90kDa alpha family class A member 1;heat shock protein 90kDa alpha family class B member 1;heat shock protein HSP 90-alpha;heat shock protein HSP 90-beta;HEL-S-65p;HSP 86;Hsp103;HSP84;HSP86;Hsp89;HSP89A;Hsp90;HSP90-beta;HSP90A;HSP90B;HSP90N;HSPC1;HSPC2;HSPCA;HSPCAL1;HSPCAL4;HSPCB;HSPN;LAP-2;LAP2;lipopolysaccharide-associated protein 2;LPS-associated protein 2;renal carcinoma antigen NY-REN-38
- Extra Details:
- HSP90A Alpha and HSP90B Beta are the two major cytosolic isoforms of the highly conserved heat shock protein 90 (HSP90) family, essential for maintaining protein homeostasis in all eukaryotic cells. While they share 85% amino acid sequence identity, the isoforms differ in structure and function: HSP90A Alpha primarily forms homodimers and is stress-inducible, whereas HSP90B Beta exists mainly as a monomer and is constitutively expressed. Both isoforms are abundantly expressed in the brain and play critical roles in the folding, maturation, and stabilization of a wide range of client proteins involved in neuronal signaling, synaptic plasticity, and cellular stress responses. These include kinases (e.g., c-Raf), transcription factors (e.g., p53), and hormone receptors-many of which are implicated in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. HSP90A Alpha and HSP90B Beta function as part of dynamic chaperone complexes, interacting with co-chaperones like Cdc37 and p23. ATP binding drives conformational changes that enable these complexes to stabilize client proteins and prevent their degradation. However, in disease contexts, this protective mechanism can inadvertently preserve toxic protein species, contributing to pathogenesis. By recognizing both HSP90A Alpha and HSP90B Beta, this antibody provides a powerful tool for researchers exploring the dual roles of HSP90 in neuronal health and disease.
- Shipping Conditions:
- Blue Ice