ISRIB

Cannot supply to this region.

SKU:: SIH-645
Additional Names:: N,N'-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]; trans-ISRIB
Molecular Weight:: 451.3
Purity:: >98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 1597403-47-8
Extra Details:: ISRIB is a blood-brain barrier-penetrant, potent, and selective inhibitor of the integrated stress response (ISR) that impairs cellular adaptation to endoplasmic reticulum (ER) stress. It potently reverses the effects of eukaryotic initiation factor 2A Alpha (eIF2A Alpha) phosphorylation (IC₅₀ ~ 5 nM), restoring protein translation capacity through a mechanism involving activation of eIF2B Beta and inhibition of PERK signaling. In addition, ISRIB suppresses ER stress-induced inflammatory gene expression and demonstrates significant neuroprotective activity, potently attenuating amyloid B Beta-induced neuronal cell death (12.5-25 nM) without affecting amyloid B Beta production. Functionally, ISRIB enhances spatial and fear-associated learning in mice, improves overall cognitive function, and has been shown to reverse hippocampal-dependent cognitive deficits in multiple traumatic brain injury models. These findings highlight its relevance in neuroscience research, particularly in studies of neurodegeneration and brain injury.