SIH-640
Compound E
Cannot supply to this region.
- SKU:
- SIH-640
- Additional Names:
- N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
- Molecular Weight:
- 490.5
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 209986-17-4
- Extra Details:
- A highly potent, selective, and cell-permeable G Gamma-secretase inhibitor that blocks the proteolytic processing of both amyloid precursor protein (APP) and Notch, with IC₅₀ values of ~3 nM¹,². By inhibiting G Gamma-secretase-mediated cleavage of APP, the compound robustly suppresses amyloid-B Beta (AB Beta) production, a key pathological driver in Alzheimer's disease⁵. In neural systems, this inhibitor demonstrates broad neuroscience-relevant activity: it reduces proliferation and promotes differentiation of neuroblastoma cells³, and it induces neuronal differentiation from stem cells⁴, making it a valuable tool for studying neurodevelopment, neural lineage specification, and disease-associated signaling pathways.
- Shipping Conditions:
- Ambient