SIH-639
P7C3-A20
Cannot supply to this region.
- SKU:
- SIH-639
- Additional Names:
- 3,6-Dibromo--fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
- Molecular Weight:
- 506.2
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 1235481-90-9
- Extra Details:
- P7C3-A20 is a neuroprotective and pro-neurogenic small molecule that acts through stimulation of NAMPT, a key enzyme in neuronal NAD⁺ biosynthesis¹. This compound enhances neuronal survival and promotes endogenous repair mechanisms following traumatic brain injury (TBI)². In mouse models of chronic TBI, P7C3-A20 also repairs blood-brain barrier integrity, halts progressive neurodegeneration by reversing tau phorphorylation³, and restores cognitive function⁴. Beyond TBI, it demonstrates robust neuroprotective activity in models of hypoxic-ischemic encephalopathy⁵. Additionally, P7C3-A20 suppresses neuroinflammation and protects retinal ganglion cells from degeneration in a rat optic nerve crush model(6), highlighting its potential across multiple forms of CNS injury.
- Shipping Conditions:
- Ambient