SIH-637
4-Octyl itaconate
Cannot supply to this region.
- SKU:
- SIH-637
- Additional Names:
- 4-Octyl methylenesuccinate; or n-Octyl 3-carboxy-3-butenoate
- Molecular Weight:
- 242.3
- Purity:
- >98%
- Source:
- Snythetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 3133-16-2
- Extra Details:
- 4-Octyl itaconate is a cell-permeable derivative of itaconic acid that activates the neuroprotective transcription factor Nrf2 through alkylation of KEAP1¹. In neural systems, Nrf2 activation is closely associated with antioxidant defense and suppression of neuroinflammatory signaling. 4-Octyl itaconate inhibits several regulated cell-death pathways relevant to neurological disease, including ferroptosis²-a major contributor to neuronal and glial oxidative injury-as well as gasdermin B-mediated pyroptosis³, a key driver of neuroinflammatory cytokine release. In addition, it enhances secretion of anti-inflammatory mediators⁴ and promotes a wound-resolving, pro-repair phenotype in activated macrophages⁵, suggesting potential to shift microglia and infiltrating myeloid cells toward a neuroprotective state in models of neurodegeneration or CNS injury.
- Shipping Conditions:
- Ambient