Allopregnanolone

Cannot supply to this region.

SKU:: SIH-582
Additional Names:: (3A Alpha,5A Alpha)-3-Hydroxy-pregnan-20-one; (3A Alpha,5A Alpha)-tetrahydroprogesterone; 3-OH-DHP
Molecular Weight:: 318.5
Purity:: >98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 516-54-1
ABP:: No Import Docs
Extra Details:: Allopregnanolone is a naturally occurring neuroactive steroid derived from progesterone, notable for its potent modulatory effects on the central nervous system. Unlike its parent hormone, Allopregnanolone lacks progestational activity and instead functions as a positive allosteric modulator of GABA_A receptors-the primary inhibitory neurotransmitter system in the brain. Through this mechanism, it enhances GABAergic signaling, promoting anxiolytic, sedative, and neuroprotective effects. In neurodegenerative disease research, Allopregnanolone has emerged as a promising therapeutic candidate due to its ability to support neuronal survival, reduce neuroinflammation, and promote neurogenesis. It has demonstrated efficacy in preclinical models of Alzheimer's disease by reversing cognitive deficits, reducing amyloid pathology, and stimulating the proliferation of neural progenitor cells in the hippocampus. These effects are particularly significant given the loss of neurogenesis and synaptic integrity observed in aging and neurodegeneration. Allopregnanolone's clinical relevance was further underscored by its FDA approval for the treatment of postpartum depression, highlighting its safety and efficacy in modulating mood and brain function. Its multifaceted actions on neural circuits, stress response systems, and cellular resilience make it a compelling molecule for ongoing research into neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases.

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