SIH-540
Tolcapone
Cannot supply to this region.
- SKU:
- SIH-540
- Additional Names:
- (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone, Tolcapone, Tasmar, Ro 40-7592
- Molecular Weight:
- 273.2
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 134308-13-7
- ABP:
- No Import Docs
- Extra Details:
- Tolcapone is a potent catechol-O-methyltransferase (COMT) inhibitor that enhances dopaminergic signaling by preventing dopamine degradation. It is clinically used in Parkinson's disease and has demonstrated neuroprotective effects by inhibiting alpha-synuclein and beta-amyloid aggregation. Tolcapone also binds transthyretin (TTR), stabilizing it and preventing TTR-induced cytotoxicity. These multifaceted actions make Tolcapone a valuable compound in neurodegenerative disease research, particularly in Parkinson's and Alzheimer's disease models.
- Shipping Conditions:
- Ambient