SIH-535
Bexarotene
Cannot supply to this region.
- SKU:
- SIH-535
- Additional Names:
- SR 11247, Targretin, 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
- Molecular Weight:
- 348.5
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 153559-49-0
- ABP:
- No Import Docs
- Extra Details:
- Bexarotene is a highly potent and selective retinoid X receptor (RXR) agonist, originally developed as an antineoplastic agent for cutaneous T-cell lymphoma. In neuroscience, Bexarotene has garnered significant attention for its ability to enhance the clearance of soluble B Beta-amyloid and improve cognitive function in animal models of Alzheimer's disease. It has also been shown to reverse apoE4-driven brain pathology and behavioral deficits, highlighting its potential in targeting genetic risk factors for neurodegeneration. By modulating lipid metabolism, inflammation, and gene expression, Bexarotene represents a promising therapeutic avenue for neurodegenerative diseases. Its dual role in oncology and neurology underscores its versatility and scientific impact.
- Shipping Conditions:
- Ambient