SIH-475
SC 514
Cannot supply to this region.
- SKU:
- SIH-475
- Additional Names:
- 4-Amino-[2',3'-bithiophene]-5-carboxamide
- Molecular Weight:
- 224.3
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 354812-17-2
- ABP:
- No Import Docs
- Extra Details:
- SC 514 is a selective and reversible inhibitor of IK KappaB kinase 2 (IKKB Beta), a key regulator of the NF-K KappaB signaling pathway. By blocking IKKB Beta activity, SC 514 prevents the phosphorylation and degradation of IK KappaBA Alpha, thereby inhibiting NF-K KappaB activation. In neurodegenerative disease research, SC 514 is used to explore the role of NF-K KappaB in neuroinflammation, glial activation, and neuronal survival. Its >10-fold selectivity over other kinases such as JNK, p38, MK2, and ERK enhances its utility in dissecting inflammatory signaling in the brain. SC 514 is cell-permeable and is a valuable compound for studying therapeutic strategies targeting chronic inflammation in neurodegenerative disorders.
- Shipping Conditions:
- Ambient