SIH-474
SB203580
Cannot supply to this region.
- SKU:
- SIH-474
- Additional Names:
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
- Molecular Weight:
- 377.4
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 152121-47-6
- ABP:
- No Import Docs
- Extra Details:
- SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase, particularly the p38A Alpha isoform. It also inhibits phosphorylation of heat shock protein 27 (HSP27) and can activate Raf-1 signaling. In neuroscience, SB203580 is used to study the role of p38 MAPK in neuroinflammation, synaptic plasticity, and neuronal survival. Its high selectivity over kinases such as LCK, GSK-3B Beta, and PKBA Alpha makes it a reliable tool for dissecting p38-mediated signaling in neurodegenerative disease models. SB203580 is cell-permeable and is frequently employed in studies of Alzheimer's disease, stroke, and other CNS disorders involving inflammatory and stress responses.
- Shipping Conditions:
- Ambient