SB202190

Cannot supply to this region.

SKU:: SIH-473
Additional Names:: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Molecular Weight:: 331.3
Purity:: ≥98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 152121-30-7
ABP:: No Import Docs
Extra Details:: SB202190 is a highly selective and potent inhibitor of p38 MAP kinase, specifically targeting the p38A Alpha and p38B Beta isoforms. It binds within the ATP-binding pocket of the active kinase, preventing phosphorylation events that drive inflammatory and stress-related signaling. In neurodegenerative disease research, SB202190 is used to investigate the role of p38 MAPK in neuronal apoptosis, synaptic dysfunction, and neuroinflammation. Its ability to induce apoptosis and modulate stress-activated pathways makes it a valuable tool for studying mechanisms underlying Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. SB202190 is cell-permeable and widely used in both in vitro and in vivo models to explore kinase-targeted neuroprotective strategies.