SIH-467
Picropodophyllotoxin
Cannot supply to this region.
- SKU:
- SIH-467
- Additional Names:
- Picropodophyllin, NSC 36407, PPP, (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- Molecular Weight:
- 414.4
- Purity:
- ≥96%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 477-47-4
- ABP:
- No Import Docs
- Extra Details:
- Picropodophyllotoxin is an inhibitor of the insulin-like growth factor 1 receptor (IGF1R), blocking its autophosphorylation and downstream signaling. In neuroscience, IGF1R signaling is associated with neuronal growth, survival, and metabolism. Picropodophyllotoxin is used to explore the role of IGF1R in neurodegenerative diseases, particularly in relation to cell cycle regulation, apoptosis, and synaptic maintenance. Its ability to modulate pAKT and pERK1/2 pathways makes it a useful compound for studying neuroprotective and neurotoxic mechanisms in the brain.
- Shipping Conditions:
- Ambient