SIH-463
Nilotinib
Cannot supply to this region.
- SKU:
- SIH-463
- Additional Names:
- 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
- Molecular Weight:
- 529.5
- Purity:
- ≥99%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 641571-10-0
- ABP:
- No Import Docs
- Extra Details:
- Nilotinib is a potent and selective inhibitor of Bcr-Abl tyrosine kinase, with additional activity against JAK2/STAT5 and MDM2 at the post-translational level. In neurodegenerative disease research, Nilotinib has gained attention for its ability to modulate autophagy and promote the clearance of misfolded proteins, such as alpha-synuclein and tau. These properties are particularly relevant in Parkinson's and Alzheimer's disease models, where impaired protein degradation contributes to neuronal dysfunction. Nilotinib's neuroprotective effects are also linked to its capacity to influence dopaminergic signaling and reduce neuroinflammation, making it a promising candidate for repurposing in neurodegenerative therapeutics.
- Shipping Conditions:
- Ambient