SIH-455
K252A
Cannot supply to this region.
- SKU:
- SIH-455
- Additional Names:
- (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
- Molecular Weight:
- 467.5
- Purity:
- ≥98%
- Source:
- Nonomuraea longicatena
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 99533-80-9
- ABP:
- No Import Docs
- Extra Details:
- K252A is a broad-spectrum protein kinase inhibitor that targets a wide range of kinases, including PKA, PKC, PKG, CaM kinase II, myosin light chain kinase (mlCK), and receptor tyrosine kinases. In neuroscience, K252A is widely used to study neurotrophic signaling, particularly through its inhibition of TrkA, the receptor for nerve growth factor (NGF). It is employed in models of neuronal differentiation, survival, and synaptic plasticity. K252A is also used to investigate the role of kinase signaling in neurodegenerative processes and to explore therapeutic strategies targeting kinase dysregulation in the brain.
- Shipping Conditions:
- Ambient