CHIR99021

Cannot supply to this region.

SKU:: SIH-437
Additional Names:: CT99021 , 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Molecular Weight:: 465.3
Purity:: ≥98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 252917-06-9
ABP:: No Import Docs
Extra Details:: CHIR99021 is a potent and highly selective inhibitor of glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase involved in numerous cellular processes. In neuroscience, GSK-3 is implicated in tau phosphorylation, synaptic plasticity, and neuroinflammation-key features of neurodegenerative diseases such as Alzheimer's and Parkinson's. CHIR99021 promotes B Beta-catenin stabilization and supports neural stem cell self-renewal and differentiation. It is widely used to study Wnt signaling, neurogenesis, and the therapeutic potential of GSK-3 inhibition in brain repair and neuroprotection.