SIH-427
AG 1517
Cannot supply to this region.
- SKU:
- SIH-427
- Additional Names:
- 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868, PD 153,035, SU 5271, 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline
- Molecular Weight:
- 360.2
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 153436-54-5
- ABP:
- No Import Docs
- Extra Details:
- AG 1517 is a potent and selective ATP-competitive inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. EGFR signaling plays a critical role in regulating cell proliferation, survival, and differentiation, and its dysregulation has been implicated in various pathological conditions, including cancer and neurodegeneration. In the context of neuroscience, EGFR is increasingly recognized for its involvement in neuroinflammatory responses, glial cell activation, and neuronal survival. Overactivation of EGFR pathways has been linked to oxidative stress and excitotoxicity-key contributors to the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. By selectively inhibiting EGFR, AG 1517 offers a targeted approach to modulating these detrimental signaling cascades. Moreover, EGFR inhibition may influence neurogenesis and synaptic plasticity, processes essential for cognitive function and brain repair. AG 1517's cell-permeable nature enhances its utility in both in vitro and in vivo models, making it a valuable tool for dissecting EGFR-mediated mechanisms in the central nervous system. While originally developed for oncology, AG 1517 is gaining traction in neurobiology as a candidate for exploring therapeutic strategies aimed at reducing neuroinflammation, promoting neuronal resilience, and mitigating the molecular drivers of neurodegeneration.
- Shipping Conditions:
- Ambient