6BIO

Cannot supply to this region.

SKU:: SIH-422
Additional Names:: (2'Z,3'E)-6-Bromoindirubin-3'-oxime, 6-BIO, 6BIO, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular Weight:: 356.2
Purity:: ≥98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 667463-62-9
ABP:: No Import Docs
Extra Details:: 6BIO is a potent, reversible, and ATP-competitive inhibitor of glycogen synthase kinase-3A Alpha/B Beta (GSK-3A Alpha/B Beta), as well as an inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Its ability to modulate the Wnt signaling pathway has made it a valuable tool in stem cell biology, particularly for maintaining self-renewal and pluripotency in embryonic stem cells. Although its primary applications have been in developmental biology and cancer research, emerging evidence suggests that GSK-3 inhibition may have neuroprotective effects. In the context of neurodegenerative diseases, 6BIO's modulation of GSK-3 activity could influence tau phosphorylation and amyloid precursor protein processing, both of which are implicated in Alzheimer's disease. This positions 6BIO as a compound of growing interest in neuroscience, particularly for its potential to modulate key signaling pathways involved in neuronal survival and plasticity.