BzATP

Cannot supply to this region.

SKU:: SIH-420
Additional Names:: 2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate tri(triethylammonium) salt
Molecular Weight:: 1018.97
Purity:: >97.7%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 112898-15-4
ABP:: No Import Docs
Extra Details:: BzATP (2',3'-O-(4-benzoylbenzoyl)-ATP) is a potent agonist of the P2X7 receptor, exhibiting significantly greater efficacy than ATP. P2X7 receptors are ATP-gated ion channels expressed predominantly in microglia and are key mediators of neuroinflammatory responses. Activation of P2X7 by BzATP induces calcium influx, cytokine release, and inflammasome activation-processes implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's, multiple sclerosis, and amyotrophic lateral sclerosis. BzATP is also used to study purinergic signaling and glial cell activation in models of brain injury and chronic inflammation. Its high potency and receptor specificity make it a valuable tool for dissecting neuroimmune mechanisms in the CNS.