SIH-404
Spautin-1
Cannot supply to this region.
- SKU:
- SIH-404
- Additional Names:
- 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
- Molecular Weight:
- 271.26
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 1262888-28-7
- ABP:
- No Import Docs
- Extra Details:
- Spautin-1 (specific and potent autophagy inhibitor 1) is a small molecule that inhibits autophagy by targeting the deubiquitinating enzymes USP10 and USP13, leading to degradation of the Beclin-1 complex. In neurodegenerative disease research, Spautin-1 is used to study the role of autophagy in neuronal survival and protein aggregation. Dysregulated autophagy is a hallmark of diseases such as Alzheimer's, Parkinson's, and Huntington's, where accumulation of misfolded proteins contributes to neurotoxicity. By inhibiting autophagy, Spautin-1 helps delineate the protective versus detrimental roles of this pathway in neuronal health and degeneration. It is a valuable tool for dissecting autophagy-related mechanisms in the CNS.
- Shipping Conditions:
- Ambient