SIH-402
AICAR
Cannot supply to this region.
- SKU:
- SIH-402
- Additional Names:
- N1-(B Beta-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
- Molecular Weight:
- 258.2
- Purity:
- >99%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 2627-69-2
- ABP:
- No Import Docs
- Extra Details:
- AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an adenosine analog that activates AMP-activated protein kinase (AMPK) upon intracellular conversion to ZMP. AMPK is a master regulator of cellular energy homeostasis and plays a pivotal role in modulating autophagy, mitochondrial biogenesis, and oxidative stress responses. In the context of neurodegenerative disease research, AICAR is of particular interest due to its ability to induce autophagy through AMPK-mediated phosphorylation of ULK1, bypassing mTORC1 inhibition. This mechanism is critical in clearing misfolded proteins and damaged organelles, processes that are impaired in disorders such as Alzheimer's, Parkinson's, and Huntington's disease. AICAR's neuroprotective potential is further supported by its capacity to enhance neuronal survival under metabolic stress, making it a valuable tool for studying energy metabolism and therapeutic strategies in neurodegeneration.
- Shipping Conditions:
- Ambient