SIH-401
Rolipram
Cannot supply to this region.
- SKU:
- SIH-401
- Additional Names:
- 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
- Molecular Weight:
- 275.35
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 61413-54-5
- ABP:
- No Import Docs
- Extra Details:
- Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor that elevates intracellular cAMP levels, thereby modulating signaling pathways involved in inflammation, neuroplasticity, and cell survival. In neuroscience, Rolipram has been extensively studied for its neuroprotective and cognitive-enhancing effects. By increasing cAMP, Rolipram enhances the activity of protein kinase A (PKA) and the transcription factor CREB, which are critical for memory formation and synaptic plasticity. It also reduces the production of pro-inflammatory cytokines, making it a promising candidate for mitigating neuroinflammation in neurodegenerative diseases such as Alzheimer's and Parkinson's. Rolipram has shown efficacy in preclinical models of depression, traumatic brain injury, and multiple sclerosis, highlighting its broad therapeutic potential in CNS disorders.
- Shipping Conditions:
- Ambient