SIH-394
Rottlerin
Cannot supply to this region.
- SKU:
- SIH-394
- Additional Names:
- 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
- Molecular Weight:
- 516.55
- Purity:
- ≥98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 82-08-6
- ABP:
- No Import Docs
- Extra Details:
- Rottlerin is a natural polyphenol known for its inhibitory effects on protein kinase C (PKC) and Ca²⁺/calmodulin-dependent kinase III. In neuroscience, Rottlerin is recognized for its neuroprotective properties, particularly in models of Parkinson's disease. It acts as a mitochondrial uncoupler, depolarizing membrane potential and influencing energy metabolism. Rottlerin also induces autophagy by inhibiting mTORC1 signaling, a pathway critical for neuronal survival and protein clearance. Its ability to modulate potassium channels and reduce oxidative stress further supports its application in neurodegenerative disease research. Rottlerin is frequently used to explore the interplay between mitochondrial function, autophagy, and neuronal health.
- Shipping Conditions:
- Ambient