ICG-001

Cannot supply to this region.

SKU:: SIH-387
Additional Names:: (6S,9aS)-Hexahydro-6-[(4-hydroxyphe-nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(-phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c-arboxamide
Molecular Weight:: 548.63
Purity:: >98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 847591-62-2
ABP:: No Import Docs
Extra Details:: ICG-001 is a selective inhibitor of the B Beta-catenin/CBP interaction, effectively modulating Wnt/B Beta-catenin signaling pathways. In neuroscience, dysregulation of Wnt signaling has been implicated in neurodevelopmental disorders and neurodegenerative diseases. ICG-001 has been used to study neuronal differentiation, synaptic plasticity, and neuroinflammation. By targeting transcriptional coactivators, ICG-001 influences gene expression profiles associated with cell survival and neurogenesis. Its application in models of brain injury and neurodegeneration highlights its potential as a therapeutic modulator of signaling pathways critical for maintaining neuronal integrity and function.