SIH-380
U0126
Cannot supply to this region.
- SKU:
- SIH-380
- Additional Names:
- 1,4-Diamino-2,3-dicyano-1,4-bis[2-a-minophenylthio]butadiene
- Molecular Weight:
- 380.5
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 109511-58-2
- ABP:
- No Import Docs
- Extra Details:
- U-0126 is a selective and non-competitive inhibitor of MEK1 and MEK2 (IC50 = 72 nM and 58 nM, respectively), key kinases in the MAPK/ERK signaling cascade. This pathway regulates cell proliferation, differentiation, and survival-processes often dysregulated in neurodegenerative diseases. U-0126 is widely used in neuroscience to investigate ERK-dependent mechanisms of synaptic plasticity, memory formation, and neuronal survival. It also inhibits AP-1 transcriptional activity and suppresses the production of inflammatory cytokines and matrix metalloproteinases, linking it to studies on neuroinflammation and glial activation. U-0126's ability to induce apoptosis under growth factor deprivation conditions further supports its use in modeling neurodegenerative stress responses. Its fluorescence properties in cell culture also make it a useful marker in imaging-based assays.
- Shipping Conditions:
- Ambient