SIH-361
Zafirlukast
Cannot supply to this region.
- SKU:
- SIH-361
- Additional Names:
- Cyclopentyl [3-(2-methoxy-4-{[(2-methylphenyl)sulfonyl]carbamoyl}benzyl)-1-methyl-1H-indol-5-yl]carbamate; ICI-204219
- Molecular Weight:
- 575.7
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 107753-78-6
- ABP:
- No Import Docs
- Extra Details:
- Zafirlukast, a leukotriene receptor antagonist and HSP70 inhibitor (IC50 = 37 uM), is primarily known for asthma treatment but is gaining interest in neurodegenerative disease research. HSP70 is a molecular chaperone essential for protein homeostasis and stress response-processes disrupted in Alzheimer's, Parkinson's, and Huntington's diseases. Zafirlukast's ability to modulate HSP70 activity and cross the blood-brain barrier makes it a promising candidate for targeting proteostasis and neuroinflammation. Its dual role in immunology and neurobiology underscores its potential for repurposing in neuroprotective strategies.
- Shipping Conditions:
- Ambient