SIH-360
Sirtinol
Cannot supply to this region.
- SKU:
- SIH-360
- Additional Names:
- 2-[[(2-Hydroxy-1-naphthalenyl)methy-lene]amino]-N-(1-phenylethyl)benzamide
- Molecular Weight:
- 394.47
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 410536-97-9
- ABP:
- No Import Docs
- Extra Details:
- Sirtinol is a selective, cell-permeable inhibitor of sirtuin deacetylases (IC50: 38 uM for SIRT2, 68 uM for Sir2p, 131 uM for SIRT1), with no effect on HDAC1. Sirtuins are key regulators of aging, stress response, and neurodegeneration. Sirtinol's specificity enables precise investigation of sirtuin-mediated pathways in neuronal survival, synaptic plasticity, and neuroinflammation. Its relevance in Alzheimer's and Parkinson's research is growing, as sirtuin-targeted therapies gain traction. Sirtinol is widely used in neuroscience to explore epigenetic mechanisms underlying cognitive decline and neuronal resilience.
- Shipping Conditions:
- Ambient