Chaetocin

Cannot supply to this region.

SKU:: SIH-351
Additional Names:: 2, 2', 3S, 3'S, 5aR, 5'aR, 6, 6'- octahydro- 3, 3'- bis(hydroxymethyl)- 2, 2'- dimethyl- [10bR, 10'bR(11aS, 11'aS)- bi- 3, 11a- epidithio- 11aH- pyrazino[1', 2':1, 5]pyrrolo[2, 3- b]indole]- 1, 1', 4, 4'- tetrone
Molecular Weight:: 696.9
Purity:: >99%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 28097-03-2
ABP:: No Import Docs
Extra Details:: Chaetocin is a fungal-derived inhibitor of the lysine methyltransferase SUV39H1, a key enzyme involved in histone H3 lysine 9 (H3K9) methylation. While primarily studied for its antimyeloma and anticancer properties, Chaetocin has gained attention in neuroscience for its role in epigenetic regulation. By modulating histone methylation, Chaetocin influences gene expression patterns critical to neuronal development, synaptic plasticity, and memory formation. Its ability to alter chromatin structure makes it a valuable tool for investigating the epigenetic mechanisms underlying neurodegenerative diseases such as Alzheimer's and Huntington's. Chaetocin's cell permeability and specificity for SUV39H1 position it as a promising candidate for exploring therapeutic strategies targeting aberrant histone methylation in the brain.