SIH-349
Bml-278
Cannot supply to this region.
- SKU:
- SIH-349
- Additional Names:
- N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
- Molecular Weight:
- 391.5
- Purity:
- >98%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- ABP:
- No Import Docs
- Extra Details:
- BML-278 is a selective, cell-permeable activator of SIRT1, a NAD⁺-dependent deacetylase involved in regulating cellular stress responses, metabolism, and aging. With high specificity for SIRT1 over SIRT2 and SIRT3, BML-278 enhances SIRT1 activity at low micromolar concentrations. In neuroscience, SIRT1 activation is associated with neuroprotection, improved mitochondrial function, and reduced neuroinflammation. SIRT1 modulates key transcription factors such as PGC-1A Alpha and FOXO, which are involved in oxidative stress resistance and neuronal survival. BML-278 is increasingly used in models of Alzheimer's and Parkinson's disease to investigate therapeutic strategies targeting age-related cognitive decline and neurodegenerative mechanisms.
- Shipping Conditions:
- Ambient