MDBN

Cannot supply to this region.

SKU:: SIH-342
Additional Names:: 3,4-Methylenedioxy-B Beta-nitrostyrene; 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole
Molecular Weight:: 193.2
Purity:: >98%
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
CAS Number:: 1485-00-3
ABP:: No Import Docs
Extra Details:: MDBN is an irreversible inhibitor of the AAA-ATPase p97, also known as valosin-containing protein (VCP), with an IC50 below 10 uM. p97 plays a central role in protein homeostasis, including ER-associated degradation (ERAD), autophagy, and stress granule dynamics. Mutations in p97 are linked to neurodegenerative disorders such as inclusion body myopathy and frontotemporal dementia. MDBN offers a pharmacological approach to modulate p97 activity and investigate its role in neuronal proteostasis and neurodegeneration.